Điều chế cefuroxim từ 7-ACA

Abstract

Cefuroxime, a second generation cephalosporin antibiotic, is synthesized from starting materials 7-ACA (7-amino cephalosporinic acid) and SMIA (2-furanyl- (Z)-2-methoxyiminoacetic acid ammonium salt). The study showed that the product could be prepared via a 4 step scheme to obtain cefuroxime in good total yield of 42 %.