Study on preparation of Chitosan nanoparticle as protein delivery carrier for drug delivery application

Abstract

This work investigates the polyanion initiated gelation process in fabricating chitosan (CS)-tripolyphosphate (TPP) nanoparticle intended to be used as protein delivery carrier. Variations in cross-linking agents, CS/TPP weight ratio and solution pH were investigated. The chitosan nanoparticles were characterized by several analytical techniques such as FT­-IR, XRD, FE_SEM and TEM. Finally, protein loading efficiency (LE) and protein loading capacity (LC) were investigated.