Anti-bacterial and anti-fungal activity of some N-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl) thiosemicarbazone benzaldehydes

Abstract

The effect of synthetic N - (2, 3, 4, 6 - tetra - O - acetyl - β -D-galactopyranosyl) thiosemicarbazone benzaldehydes against the growth of bacteria and fungi were investigated. The results showed that all compounds significantly inhibited the growth of Klebsiella pneumonia, Staphyloccous epidermidis and Candida albicans at concentration of 40µL. The structure-bioactivity relationships were studied and the regression equation built with relative coefficients in the range of 0.91 - 0.99