Assessment of single nucleotide polymorphism RS2596542 of MICA gene among nasopharyngeal cancer patients

Abstract

MICA is an antigen that is commonly expressed on cell surface of tumoRS. MICA had a low expression level in normal cells but increased in pathological/cancer cells. The goal of the study was to determine the association of SNP RS2596542 with the risk of nasopharyngeal cancer (NPC). 144 biopsy samples diagnosed with NPC and 135 blood samples from healthy people were collected. Genotypes and alleles of RS2596542 MICA were determined by Realtime PCR genotyping. The genotype rate of MICA at RS2596542 in patients with NPC was 34.72% CC; 44.44% CT and 20.84% TT. The genotype of TT and T allele in the disease group was significantly higher than the control group (p=0.01*; OR=2.47; 95%CI: 1.22-4.97) and (p=0.01*; OR=1.51; 95%CI: 1.07-2.13). The T-allele at SNP RS2596542 of the MICA gene increases the risk of NPC and suggests that this could be used as a biomarker for NPC screening in Viet Nam.