XÂY DỰNG PHƯƠNG PHÁP PHÂN TÍCH DƯ LƯỢNG CÁC CHẤT VÔ CƠ TRONG NƯỚC THẢI TỪ QUY TRÌNH SẢN XUẤT KETAMIN BẰNG KỸ THUẬT PHỔ KHỐI NGUỒN PLASMA CẢM ỨNG (ICP-MS)

Tóm tắt

During the synthesis of ketamine, some inorganic elements might be present in wastewater. The
determination of these elements provides useful information for investigation of illegal manufacturing
site of ketamine. In this study, an analytical method for simultaneous determination of 8 inorganic
elements namely Br, I, P, Mn, Al, Pd, Zn, Cu at trace level using inductively coupled plasma-mass
spectrometry (ICP-MS). Validation results revealed high repeatability, good recovery (82.2 to 101.6%),
good linearity (correlation coefficients of 0.996 – 1.000) within investigated range of 0.9 ppb to 55.5 ppb,
and high sensitivity with limit of quantitation (LOQ) of 0.2 ppb to 16.0 ppb for element.