NITROGEN HETEROCYCLIC CARBENE -CATALYZED RING OPENING OF OXAZOLONES WITH ALCOHOLS

Abstract

An efficient synthesis of α-amino ester from easily accesible oxazolones was reported. The ring opening of
oxazolones with alcohols proceeded smoothly at room temperature in the presence of sodium carbonate as a
base and a triazolium as precatalyst to furnish α-amino esters in high yields. This methodology showed good
tolerance to many oxazolones with different substituents, as well as to different alcohols, providing a broad scope
of α-amino carbonyl compounds.