C-acetylation some aryl methyl ethers in green chemistry conditions

Abstract

Alkyl aryl ketone is an important intermediate in the synthesis of biologically active molecules. It is usually synthesized by Friedel-Crafts acylation of aromatic compound in the presence of excess Lewis acid, AlCl3. In this study, copper triflate Cu(OTf)2, was used as a new generation Lewis acid catalyst in Friedel-Crafts acylation. The reaction was taken place under microwave irradiation on anisole and veratrole. Copper triflate is safe-to-handle, recoverable and reusable