ASSESSMENT OF MINERAL AND BONE DISORDERS IN KIDNEY TRANSPLANT RECIPIENTS AT PEOPLE'S HOSPITAL 115

Abstract

Objectives: To assess mineral and bone disorder prevalence, to analyze correlation with post-transplant time, and to determine bone mineral density changes over time in kidney transplant recipients.

Methods: A cross-sectional study was conducted on 135 kidney transplant recipients at People's Hospital 115. Biochemical parameters and bone mineral density were evaluated using DEXA.

Results: The prevalence of hyperparathyroidism was 78.5%, of hypophosphatemia was 17.8%, and of hypercalcemia 17.0%. Osteoporosis was more common in the lumbar spine (11.9%) than femoral neck (8.9%). Lumbar spine T-score showed a trend toward improvement over time, from -1.50 (-2.30 to -0.60) at 24-60 months to -0.50 (-1.20 to 0.10) at >120 months (p = 0.136), with a trend toward positive correlation with post-transplant time (r = 0.16, p = 0.058).

Conclusions: Hyperparathyroidism is the most common mineral and bone disorder after kidney transplantation. Lumbar spine bone density shows a trend toward improvement over time. Long-term management strategies are necessary for mineral and bone disorders in kidney transplant recipients.

Keywords: kidney transplantation; mineral and bone disorders; bone mineral density; hyperparathyroidism; osteoporosis