CHARACTERISTICS OF PSA LEVELS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA UNDERGOING SURGERY AT THAI BINH UNIVERSITY MEDICAL HOSPITAL

Abstract

Background: How does lower urinary tract obstruction affect PSA level changes in patients with benign prostatic hyperplasia.

Objectives: (1) describe the changes in PSA levels. (2) Explore factors related to changes in PSA levels.

Methods: Cross-sectional study was conducted on 108 cases of transurethral endoscopic prostatectomy with histopathological results of benign prostatic hyperplasia.

Results: The number of cases with PSAt concentration ≤ 4 ng/ml accounted for 28.7%, whereas PSAt concentration > 10 ng/ml took up 27.8%. The PSAt concentration of the study group averaged 9.09±8.80 ng/ml; with the median at 6.20 ng/ml. The proportion of prostate-specific antigen density (PSAD) < 0.15 ng/ml2 was 57.4%, and PSAD ≥ 0.15 ng/ml2 was 39.8%. The mean PSAD of the study group was 0.15±0.13 ng/ml2; the median was 0.11ng/ml2. Prostate volume and PSA concentration were strongly positively correlated with r = 0.36; p <0.001.

Conclusions: PSA levels in patients with benign prostatic hyperplasia are highly variable with multiple recorded extreme values. PSAD is proven to be a more valuable index for analyzing PSA levels in this disease. Lower urinary tract obstruction, age, and especially prostate volume are positively correlated with an increase in PSA levels.

Keywords: prostate specific antigen; benign prostatic hyperplasia