SYSTEMIC IMMUNE-INFLAMMATION INDEX IN DIABETIC PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE

Abstract

Background: Systemic immune-inflammation index (SII) is a recently discovered inflammatory marker and is associated with the development of diabetic chronic kidney disease. The study was conducted to determine the relationship between SII and kidney disease assessment indicators in type 2 diabetic patients.

Objectives: To survey clinical characteristics of diabetics with and without chronic kidney disease, and compare the correlation between SII and kidney disease assessment indicators in the two groups.

Methods: Cross-sectional study on 85 patients with type 2 diabetes at the outpatient clinic of the University Medical Center, Ho Chi Minh City from August 2024 to January 2025.

Results: The median SII in the study group was 474.46. In the diabetic group with chronic kidney disease, there was a negative correlation between HbA1c and the mean SII (r = –0.403). Meanwhile, in the diabetic group without chronic kidney disease, this correlation was positive at a low level (r = 0.174), with a statistically significant difference

(p <0.05).

Conclusions: Chronic inflammation can affect HbA1c in diabetic patients with renal complications

Keywords: systemic immune-inflammation index; diabetes; chronic kidney disease