CLINICAL SYMPTOMS, PARACLINICAL CHARACTERISTICS, AND FROZEN-SECTION BIOPSY RESULTS OF PATIENTS WITH LARYNGEAL CANCER TREATED WITH TRANSORAL LASER MICROSURGERY AT EAR NOSE THROAT HOSPITAL OF HOCHIMINH CITY FROM 06/2020 TO 06/2021

Abstract

Background: Early diagnosis of laryngeal carcinoma is necessary for transoral laser microsurgery.

Methods: Patients with laryngeal carcinoma who had transoral laser microsurgery at ENT hospital of Hochiminh City. Cross-sectional study and retrospective study.

Results: The major reason for hospitalization is voice hoarseness. We found anterior commissure invasion (53.3%) and laryngeal ventricle invasion (13.3%) on flexible laryngoscopy. We found commissure invasion (26.7%) and laryngeal ventricle invasion (6.7%) on direct laryngoscopy under general anesthesia. For tumor staging (AJCC 7), we found that stage 0 was 10%, stage I was 83.3%, and stage II was 6.7%. Post-operative pathology showed that carcinoma in situ was 10%, high-differentiated squamous cell carcinoma was 33.3%, and moderately-differentiated squamous cell carcinoma was 56.7%. Six cases had positive margin (20%), which included: anterior margin (66.7%), posterior margin (16.7%), and inferior margin (16.7%).

Conclusions: Early diagnosis of laryngeal carcinoma is necessary for transoral laser microsurgery. Transoral laser microscopy and frozen-section biopsy is effective for the treatment of early glottic carcinoma.

Keywords: frozen-section biopsy, laryngeal carcinoma, microsurgery