Study of blending suspension solid lipid nanoparticles (SLNs) gac (Momordica Cocochinenis Spreng.) Into skin cream

Abstract

     Solid lipid nanoparticles Gac (SLNs Gac) suspension were prepared by using Emulgade SE-PETM lipid with the support of surfactant. The SLNs FREE was prepared at the same conditions as a control sample to compare with SLNs-GAC. SLNs-FREE and SLNs-GAC were then mixed to a skin cream at different concentrations of 5%, 10%, 15% (w/w). The stability of the mixture was then examined through the effect of centrifugal speed, ultrasound treatment, thermal shock (temperatures of 10oC, ambient temperature and 45°C) through color measurement and texture measurement of the skin cream. The results showed that the color of cream when mixing either with SLNs-GAC or with SLNs-FREE slowly changed at 10oC but very fast changed at 45oC and the texture measurement of skin cream was stable and homogenous.