Determination of acute toxicity and anti – inflammatory activity of Gomphrena celosioides Amaranthaceae extract

Abstract

   Introduction: In Viet Nam, the study of No ngay dat (Gomphrena celosioides Mart.) is still limited. Therefore, this study was conducted for the purpose of determining acute toxicity and evaluating the anti - inflammatory effects of Gomphrena celosioides aqueous extract.Materials and Methods: To determine acute toxicity, the study enrolled mice for oral dosing at the maximum possible oral dose and recorded live or death of mice in the next 72 hours. A carrageenan - induced paw edema assay was performed to evaluate the anti-inflammatory effects of Gomphrena celosioides. After inflammation, the mice were given a therapeutic dose and monitored the paw volume every day during the test.Results and Discussion: The results showed that aqueous extract at 11,8g/kg (Dmax) did not kill the test mice and not have acute oral toxicity. Besides that, aqueous extract also has anti-inflammatory effect at 300mg/kg and 600mg/kg.Conclusion: Gomphrena celosioides is not toxic at the tested dose and shows significant anti - inflammatory activity. This is a highly potential medicinal plant for the treatment of inflammatory diseases and should be isolated some bioactivity compounds or investigates the others pharmacological effects.