Study on preparation of self micro-emulsion system (smedds) containing atorvastatin

Abstract

 Atorvastatin (ATV) is the first group of medicines to treat hyperlipidemia. However, ATV‟s low solubility in water reduced bioavailability. There are many methods to improve ATV‟s solubility. In particular, Self - microemulsifying drug delivery system (SMEDDS), having many advantages in increasing solubility, stability and simple modulation methods, is selected in this study. Materials and methods: Materials: Raw ATV is imported from India by Hau Giang Pharmaceutical Joint Stock Company. Methods: Preparation of SMEDDS formulas with ATV, survey of SMEDDS criteria for durability and stability in different environments. Results: CT3 (capryol 90 - 20%; acrysol K-140 - 30%; transcutol HP - 50%) is the formula for endurance tests in those environments. The ATV's loading capacity of SMEDDS is 7.5% and it is stable for 30 days.Conclusion: CT3 is a potent formula in research formulas of SMEDDS containing ATV.