Characterising the Properties of Nano Silver Loaded Poly (Vinyl Alcohol) on Glutaric Anhydride

Abstract

     Hydrogel poly (vinyl alcohol) is a network of Polyvinyl alcohol (PVA) polymers which has various application in biomedicine, especially in wound healing. In wound treatment, the hydrogel should have strong stability as well as anti-bacteria effect in order to protect the opened wound from physical and biological interaction. For these purposes, the study on the characterization of silver nanoparticle loaded hydrogel Poly (vinyl alcohol) Glutaric anhydride has been done. The polymer also had its stability reinforced through the cross-linking between the poly (vinyl alcohol) and the solidifier glutaric anhydride structures. The results on Fourier transformed infrared spectrum have shown the bonding between PVA polymer via (−OCO) at the wave length    1,700 cm^-1. The PVA-GA hydrogel has lower degradation rate than the control (17 % vs 25 %). In biological test, the PVA –GA Ag nanoparticles have proved the ability to eradicate the P. aeruginosa after 2 hours and S. aureus after 4 hours after directed contact. These results in vitro have proved the statbility and antibacterial effect of PVA-GA- Nano Ag. Even though more tests should be performed, the hydrogel has showed great potential in wound healing.