ANTI-INFLAMMATORY AND INHIBITION OF ENZYME XANTHINE OXIDASE ACTIVITY OF SOME SPECIES OF GNETUM

Abstract

Three ethanol extracts (GL, GMQT, GMVP) were extracted from Gnetum
latifolium var. funiculare Markgr. collected in Tay Nguyen province, Gnetum
montanum Markgr collected in Quang Tri and Vinh Phuc province. Investigating
their biological activity showed that all of them can inhibit enzyme xanthine
oxidase and anti-inflammatory through the inhibition of NO prodution. Of these,
the inhibition of NO prodution of three extracts are very good, especially the
GMVP extract with IC50 21.33 ± 2.01µg/mL. The inhibition of the enzyme
xanthine oxidase of GL extract gave the best result with IC50 66.01 ± 3.63µg/mL.