SYNTHESIS, CHARACTERISTICS OF CURCUMIN-LOADED MICELLAR NANOSYSTEM

Abstract

Targeting delivery system use natural drugs for tumor cells is an appealing platform help to reduce the side effects and enhance the therapeutic effects of the drug. In this study, we synthesized curcumin (Cur) loaded (D, L Polylactic - Polyethylen glycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3/1 (w/w). The PLA-PEG copolymer was synthesized by ring opening polymerization method. After loading onto the micelle, solubility of Cur increased to 0.73 mg.ml^-1. The average size of prepared Cur/PLA-PEG micelles was 69 nm and the drug encapsulating efficiency was 91.3%. The results demonstrated that micelle (Cur/PLA-PEG) could serve as a potential nano carrier to improve solubility of the nanosystem