STUDY ON CHEMICAL CONSTITUENTS AND -GLUCOSIDASE INHIBITORY ACTIVITY OF THE ETHYL ACETATE EXTRACT FROM STEM OF MANGIFERA REBA

Abstract

The ethyl acetate extract from the stem of Mangifera reba isolated 5,7-hydroxychromone (1), gallic acid (2) and methyl gallate (3). The chemical structures of these compounds were elucidated based on the NMR spectroscopic analysis and comparison with the literatures. All isolated compounds were tested α-glucosidase inhibitory activity. Compounds 1 and 2 showed more potent inhibitory activity, with IC₅₀ values 27.0 and 50.9 μM respectively, than that of a positive control acarbose (IC₅₀, 214.5 μM)