Investigation of antibacterial activities of wells-dawson polyoxometalates

Abstract

The study was conducted to investigate the antibacterial activity of 8 Wells-Dawson polyoxometalate (POM) compounds including a-K₆P₂W₁₈O₆₂.14H₂0  and b-K₆P₂W₁₈O₆₂.19H₂O (P₂W₁₈), K₁₀[a₂-K₆P₂W₁₇O₆₁].20H₂O (P₂W₁₇), 
K₁₅H[Ce^IV(a₂-P₂W₁₇O₆₁)₂].25H₂O (Ce^IVWD 1:2), K₁₅H[Zr(a₂-P₂W₁₇O₆₁)₂].25H₂O (ZrWD 1:2), Na₁₄[Zr₄(P₂W₁₆O₅₉)₂ (m₃-O)₂(OH)₂(H₂O)₄].57H₂O (ZrWD 4:2), a₂-K₈P₂W₁₇O₆₁(Co^II.H₂O).16H₂O (CoWD 1:1), a₂-K₈P₂W₁₇O₆₁(Ni^II.H₂O).17H₂O (NiWD 1:1) và a₂-K₈P₂W₁₇O₆₁(Cu^II.H₂O).16H₂O (CuWD 1:1) against 5 bacterial strains including Escherichia coli, Salmonella spp., Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. The antibacterial activity of all 8 Wells-Dawson POM compounds was examined by the agar well diffusion method and/or the 2-fold serial dilution method. The experimental results showed that for 3 bacterial species Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, all 8 WD-POM compounds showed antibacterial activity. Among them, P₂W₁₈ showed the best antibacterial activity against all 3 bacterial strains and the minimum inhibitory concentration (MIC) values ​​were determined to be 0.1875 mM, 6, 3, and 6 times lower than the MIC values ​​of the tetracycline positive control, respectively. For Escherichia coli, only P₂W₁₈showed antibacterial ability with an average inhibition zone of 7,33±0,58 mm, about 4 times smaller than that of the tetracycline positive control. For Salmonella spp., all 8 Wells-Dawson POM compounds did not show antibacterial ability.