EFFECT OF LOADED ANASTROZOLE ON PHYSICOCHEMICAL CHARACTERIZATIONS OF THE NANOCOMPOSITE, 2-HYDROXYPROPYL-β-CYCLODEXTRIN/ALGINATE

Abstract

Nanocomposites based on natural polysaccharides, 2-hydroxypropyl-β–cyclodextrin and alginate as an effective drug nanocarriers for anastrozole have been synthesized and  well defined by physicochemical characterizations. The nanocomposites were produced from alginate and 2-hydroxypropyl-β-cyclodextrin (HPCD) by using the ionotropic gelation method which carried out based on electrostatic interactions between Ca²⁺/alginate gel and HPCD. The present work showed that content of anastrozole principly effected not only on the size, shapes of the nanocomposites but on their absorption and thermal properties. The results showed that the content of anastrozole (5%) might be suitable to prepare the spherical nanocomposites with small size and uniform distribution.

Keywords: Nanocomposite, hydroxypropyl-β-cyclodextrin, alginate, anastrozole, gelation.