Study on evaluation the incompatibility of modafinil with some excipients and solubility and dissolution rate

Abstract

Modafinil has been used as ”smart drugs”, was manufactured by Cephalon Pharmaceutical Company, Pennsylvania. It was approved by the FDA in 1998 to treat narcolepsy. In previous studies, modafinil was easily synthesized in three stages via the Bunte salt intermediate, yield above 70%. The results of quality assessment of the product after synthesis met the requirements of USP 41. This article presented the results of research to evaluate the incompatibility of modafinil active ingredient with some excipients and solubility, dissolution rate of them, as the basis for preparation of modafinil in tablet form.