ISOLATION OF POLYSACCHARIDES FROM HERICIUM ERINACEUS AND THEIR ANTI-TUMOR ACTIVITY

Abstract

Polysaccharides from fruiting body of Hericium erinaceus were isolated using hot water and akaline solution and their contents were determined. Polysaccharides extracted with 4 % NaOH were accounted for over 80 % of total polysaccharides and contained both water soluble and insoluble forms. A small amount of polysaccharides was also detected in the cultured medium. The water soluble, NaOH- extracted polysaccharides showed inhibitory activity against tumor forming of Hepatocellular carcinoma cells (Hep-G2) by decline in dimentions of tumors and tumor forming density 24.4 % , 61.5 % respectively, in comparion to no-treated cells (control).