Preparation of Erlotinib hydrochloride

Abstract

Erlotinib hydrochloride (Tarceva) is a targeted cancer therapy drug approved for treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. An efficient and economical synthetic method of title compound from ethyl 3,4- dihydroxybenzoate is described in 6 steps with overall yield of 51 %.