Analysis of EGFR mutations in paraffin-covered tissue samples and some related factors from non-small cell lung cancer patients over 60 years old

Abstract

Objective: to describe EGFR mutation status detected in tissue samples and analyse some related factors in NSCLC patients over 60 years old. Methodology: detecting EGFR mutations by Strip Assay Kit from 351 tissue samples of NSCLC patients at Bach Mai Hospital 2017-2018. Results: ratio of EGFR is 38.2%, including exon 19 deletion mutation (48.6%), exon 21 point mutation (41.6%), exon 18 point mutation (4.9%), and T790M resistant mutation on exon 20 (4.9%). The mutant rate in females (66.7%) is higher than in males (27.5%), and shows a higher rate in non-smokers (53.3%) compared to smokers (30.3%). Conclusions: the EGFR mutation ratio in NSCLC patients over 60 years is relatively high, the frequent mutant sites are exon 19 and 21. Mutations are more common in women and non-smokers. The maxSUV value of primary lung tumors in patients with gene mutations is lower than in the non-mutant group.