Bacopa monnieri extract ameliorates core autistic behavioural deficits of sodium valproate-induced autism spectrum disorder in mice, and its mechanism of action related to PTEN protein

Authors

  • Thi Nguyet Hang Pham*, Nguyen Hong Tran, Thi Xoan Le
  • Anh Tung Pham, Thi Lap Nguyen
  • Thi Hien Nguyen

Keywords:

anxiety, ASD, Bacopa monnieri, self-repetitive behaviour, social interaction, sodium valproate.

Abstract

Our previous study demonstrated the effect of Bacopa monnieri extract (BME) on behavioural deficits in sodium valproate (VPA)-induced autism spectrum disorder in mice. The present study aims to further investigate the effect of BME on neurobehaviors of autism spectrum disorder (ASD) in mice and the biochemical mechanism(s) involved...

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Author Biographies

  • Thi Nguyet Hang Pham*, Nguyen Hong Tran, Thi Xoan Le

    Department of Pharmacology and Biochemistry, National Institute of Medicinal Materials

  • Anh Tung Pham, Thi Lap Nguyen

    Hanoi University of Pharmacy

  • Thi Hien Nguyen

    Ha Dong Medical College

Published

2022-05-20