Inhibitory effects on Helicobacter pylori of methanol extracts from plants collected in Lam Dong province

Abstract

World Health Organization has recently categorised H. pylori infection as a class I gastric carcinogen. Many medicinal plants have traditionally been used for gastrointestinal problems. This study aims to evaluate the inhibitory effect on H. pylori activity of plant extracts collected in Lam Dong province. The broth microdilution method was used in vitro. The research results have identified 10 extracts that can inhibit H. pylori at a concentration of 100 mg/ml. In which there were five samples of complete inhibition: Mahonia nepalensis DC.ex Dipple, Derris malaccensis Prain, Desmodium laxiflorium DC, Hedyostics capitellata var. pubescens Kurz, and Aralia hiepiana J. Wen & Lowr. Five anti- H. pylori samples with the antibacterial diameter (mm) of a zone of inhibition 6-7 mm: Mitrephora thorelii Pierre, Embelia ribes Burn, Maclura fruticosa (Kurz), Impatiens lanbianensis Tardieu, and Prunus javanica (Teijsm & Binn.) Miq. The results have never been published before. They are the basis to expand the evaluation of anti- H. pylori activity of other plants to the search for species with potential for use in the treatment of H. pylori in Vietnam.