A review: phospholipase C zeta (PLCζ) impacts fertilisation and improves human-assisted reproductive technology

Abstract

The change of concentration of intracellular Ca²⁺ oscillations leads to oocyte activation and preparation for early embryogenesis. Phospholipase C zeta (PLCζ) plays an essential role in fertilisation. Clinical reports have suggested a link between defective PLCζ and male infertility. In particular, oocyte activation deficiency was mentioned as the cause of failure in many cases of infertility treated ith intracytoplasmic sperm injection