Culture of EV71 virus in wave bioreactor system for production of hand, foot and mouth disease vaccine

Authors

  • Thi Yen Nhi Nguyen, Thi Hanh Lan Nguyen, Ngoc Khanh Quynh Hoang, Thi Lien Le, Ha Tam Duong Le, Thi Bao Van Cao
  • Thi Yen Nhi Nguyen
  • Thi Bao Van Cao*

Keywords:

Cytodex 1, EV71, HFM vaccine, Vero cell, Wave bioreactor.

Abstract

The study was carried out to establish an EV71 virus culture system on Vero cells in a shake culture system (Wave bioreactor) incorporating microcarriers for
the production of hand, foot and mouth (HFM) vaccine caused by the EV71 virus. The results of the investigation of 2 types of microcarriers (Cytodex 1 and
Cytodex 3), showed that Cytodex 1 gave better efficiency when culturing Vero cells in suspension conditions...

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Author Biographies

  • Thi Yen Nhi Nguyen, Thi Hanh Lan Nguyen, Ngoc Khanh Quynh Hoang, Thi Lien Le, Ha Tam Duong Le, Thi Bao Van Cao

    Pasteur Institute in Ho Chi Minh city

  • Thi Yen Nhi Nguyen

    University of Science, Vietnam National University, Ho Chi Minh city

  • Thi Bao Van Cao*

    Vancao Medipharm Technology Institute

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Published

2022-09-22

Issue

Vol. 64 No. 9B (2022): Tập 64 - Số 9 - Tháng 9 - năm 2022

Section

KHOA HỌC Y - DƯỢC