Evaluating the effect of screening dual HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR technique on reducing the risk of Carbamazepine-induced hypersensitivity reactions

Authors

  • Thi Ngoc Hao Vo1, Van Son Chu, Thi Van Anh Nguyen*
  • Doan Thuy Nguyen, Van Lieu Nguyen
  • Van Lieu Nguyen

Keywords:

Abstract

Human leukocyte antigen (HLA) gene polymorphisms HLA-A*31:01 and HLA-B*15:02 are strongly associated with Carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs). As a result, it is recommended to screen these two alleles before CBZ therapy to reduce the risk of drug allergy...

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Author Biographies

  • Thi Ngoc Hao Vo1, Van Son Chu, Thi Van Anh Nguyen*

    Key Laboratory of Enzyme and Protein Technology,
    University of Science, Vietnam National University, Hanoi

  • Doan Thuy Nguyen, Van Lieu Nguyen

    Neurology and Stroke Department, Tam Anh General Hospital

  • Van Lieu Nguyen

    Department of Neurology, Hanoi Medical University

Published

2023-05-17

Issue

Vol. 65 No. 5B (2023): Volume 65 - Number 5 - May 2023

Section

KHOA HỌC Y - DƯỢC