In silico and in vitro study on apoptosis in MCF-7 human breast cancer cells lines via caspase-3 activation of Markhacanasin A

Abstract

Markhacanasin A (MA), a cycloartane-type triterpenoid was isolated from the leaves of Markhamia stipulata var. canaense V.S. Dang, collected in Ninh Thuan province, Vietnam. In our previous study, it was found that MA possessed potential cytotoxicity against MCF-7 human breast cancer cell lines, with an IC₅₀=16.51±0.22 μM. However, the mechanism by which MA triggers apoptosis in the MCF-7 cells has not been explored yet...