Expression and purification of truncated recombinant human angiotensin-converting enzyme 2 (trhACE2) capable of binding spike protein of SARS-CoV-2

Authors

  • Thi Le Thuy Nguyen*, Minh Tuan Nguyen, Thi Kim Tram Pham, Dang Quan Nguyen
  • Minh Tuan Nguyen

Keywords:

E. coli, SARS-CoV-2, spike protein, trhACE2.

Abstract

SARS-CoV-2 infects the host through the interaction between spike protein and the ACE2 (Angiotensinconverting enzyme 2) receptor on the host cell surface.
Therefore, ACE2 is considered as a key target in drug development against COVID-19. In this study, we generated the truncated recombinant human ACE2
(trhACE2) expressed on Escherichia coli and evaluated its binding activity to spike protein of SARS-CoV-2...

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Author Biographies

  • Thi Le Thuy Nguyen*, Minh Tuan Nguyen, Thi Kim Tram Pham, Dang Quan Nguyen

    Ho Chi Minh City Biotechnology Center,
    2374 National Highway 1A, Quarter 2, Trung My Tay Ward, District 12, Ho Chi Minh City, Vietnam

  • Minh Tuan Nguyen

    Ho Chi Minh City University of Technology, Vietnam National University - Ho Chi Minh City,
    268 Ly Thuong Kiet Street, Ward 14, District 10, Ho Chi Minh City, Vietnam

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Published

2024-02-25

Issue

Vol. 66 No. 2B (2024): TẬP 66, SỐ 2, THÁNG 2 NĂM 2024

Section

KHOA HỌC Y - DƯỢC