Recent advances in the pathophysiology of ovarian cancer and clinical implications for screening and intervention
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Abstract
New evidence in ovarian cancer shows that advanced-stage, high-grade serous tumors often originate from precursor epithelial lesions in the distal fimbriated end of the fallopian tube. This stands in stark contrast to endometrioid tumors and low-grade clear cell tumors, which tend to present early and may originate from borderline serous carcinoma or endometriosis. This article aims to explore novel insights into the pathophysiology of different epithelial ovarian carcinoma groups, with implications for potential screening and intervention methods in the future.
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