Synthesis and properties of some compounds containing pyrimidine heterocycle

Abstract

Starting from thiourea and acetylacetone, the 4-amino-5-[(4,6-dimethylpyrimidin-2-ylthio)methyl]-1,2,4-triazole-3-thiol compound (3) has been synthesized. Compound (3) on reaction with aromatic aldehydes in the presence of acetic acid gave hydrazones (4a-e). Compound (3) on reaction with 2-bromoacetophenones or 3-(2’-bromoacetyl)coumarines gave derivatives containing thiadiazine heterocycle (5a-f). The structures of the compounds have been confirmed by spectral IR, MS, 1D NMR and 2D NMR. Some of the new synthetic compounds were also screened for their antibacterial and antifungal activities.

Keywords: pyrimidine,1,3,4- thiadiazine,  hydrazon,  3-(2’-bromoacetyl)coumarine