ALPHA-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT ACTIVITIES OF ETHYL ACETATE EXTRACT FROM Graphis sp. MYCOBIONT

Tóm tắt

Lichens, formed by the symbiosis of fungi and algae or cyanobacteria, are increasingly recognized for their potential medicinal properties, including their potential to treat type 2 diabetes. Many studies have shown that the bioactive metabolites of lichens originate from their fungal partners. This study isolated the mycobiont from a Graphis lichen sample and investigated the antioxidant and α-glucosidase inhibitory activity of its ethyl acetate extract. The extract exhibited weak DPPH radical scavenging activity but a significant α-glucosidase inhibitory activity, with an IC50 value of 43.3 ± 1.9 μg/mL. The results suggest that lichens have the potential to control postprandial hyperglycemia and highlight the potential of Graphis sp. mycobionts as a promising source for the management of type 2 diabetes