Investigation of the acute dyslipidemia regulating effect of DNC An Duong hard capsules in mice

Abstract

The DNC AN DUONG capsules prepared from Momordica charantia, Mimosa pudica species, and Rhizoma curcumae longae were evaluated for lipid-lowering effect in vivo in mice. Experimentally, at both tested doses of 300 mg/kg and 600 mg/kg, DNC AN DUONG capsules exhibited hypolipidemic effect in mice with tyloxapol-induced hyperlipidemia. The LDL-cholesterol level decreased remarkably and the HDL-cholesterol level increased significantly in the group treated with 300 mg/kg of DNC AN DUONG in comparison with the control untreated group of mice. In addition, triglyceride-lowering and HDL cholesterol-increasing effects of the DNC AN DUONG capsules at the dose of 300 mg/kg dose were similar to the reference fenofibrate at the dose of 50 mg/kg.