Investigation of the antioxidant effect and ability to inhibit α-glucosidase enzyme in vitro of Sauropus Androgynus (L.) Merr. Leaves

Abstract

One of the ways to help reduce the amount of glucose absorbed into the blood in the treatment of diabetes is to inhibit the α-glucosidase enzyme. Sauropus androgynus (L.) Merr. contains many biologically active ingredients with the potential for anti-oxidation and supporting the treatment of diabetes. The project investigates the antioxidant effect using the DPPH free radical reduction model and the ability to inhibit the α-glucosidase enzyme of Sauropus androgynus (L.) Merr. leaves by pNG substrate cleavage reaction. The results show, the oxidation effect with EC₅₀>256 mg/mL, comparing the reference standard quercetin=9.97 ± 0.25 mg/mL and the α-glucosidase inhibitory effect with IC₅₀=10.91 ± 0.21µg/mL comparing acarbose standard IC₅₀=134.56 ± 3.02 µg/mL. Potential oxidative effects and α-glucosidase inhibition of Sauropus androgynus (L.) Merr. needs to be studied more deeply into functional foods and drugs.