CURCUMIN DRUG RELEASING OF CaTiO3 FILM ON Ti FOR POTENTIAL APPLICATION IN BIOMEDICINE

Abstract

A CaTiO₃ coating on a Ti substrate was fabricated by a hydrothermal method at 200°C for 24 hours. The Ca element in the material is an essential component in bone, enhancing biocompatibility. The structure and properties of the material were characterized by X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). The process of drug loading and release of curcumin was conducted in phosphate-buffered saline (PBS). The curcumin drug loading ability of the CaTiO₃ membrane was recorded by confocal laser scanning microscopy (CLSM). The release of curcumin was studied by an enzyme-linked immunosorbent assay (ELISA) over 72 hours. The results of curcumin releasing showed that the percentage of curcumin releasing was 69.32% compared to the initial amount. This study suggests that the CaTiO₃ coating on a Ti substrate has potential applications in biomedicine.