ANTIOXIDANT, ANTIBACTERIAL AND ANTI-INFLAMMATORY OF ESSENTIAL OILS FROM Zingiber zerumbet RHIZOMES CULTIVATED IN BUON MA THUOT CITY

Abstract

Zingiber zerumbet (L.) Roscoe ex Sm. commonly known as bitter ginger, is used in traditional medicine to treat inflammation, rheumatism, sprains, colic pain, diarrhea, tonsillitis, and other ailments. This study aims to evaluate the essential oils extracted from mature rhizomes of Zingiber zerumbet cultivated in Buon Ma Thuot city for their antioxidant, antimicrobial, and anti-inflammatory properties. Using three in vitro models of antioxidant activity, it was shown that the antioxidant capacity of essential oils from Zingiber zerumbet rhizome was found to be independent of polyphenol content. Antibacterial testing revealed that the essential oils depends on the volatile components and effectively inhibited Staphylococcus aureus (IC₅₀ = 28.911± 5.275 mg/mL) and Pseudomonas aeruginosa (IC₅₀ = 32.900 ± 5.722 mg/mL) but had limited activity against Escherichia coli. The essential oil of Zingiber zerumbet has potential applications in pharmaceuticals due to its antioxidant, antibacterial, and anti-inflammatory properties, but further studies are needed to optimize extraction methods and elucidate its mechanisms of action.