CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF EXTRACTS TOTAL FROM STEM OF Adiandra megaphylla HU COLLECTED IN LAO CAI, VIETNAM

Abstract

Adinandra megaphylla Hu which belongs to Adinandra genus narrowly distributes in Lao Cai province, Vietnam. In this study, chemical compositions and biological activities of the extracts from A. megaphylla Hu’s stem were initially investigated. The stem extracts of A. megaphylla Hu have been quantified and determined whether they contain coumarins and polyphenolic compounds. The ethanol extract, ethyl acetate extract and dichloromethane extract at the different concentrations all can inhibit the growth of Bacillus subtilis, Lactobacillus plantarum, and Escherichia coli, however the extracts with low concentrations cannot influence the growth of Seratia marcescens and Sarcina lutea except dichloromethane 60 and 200 µg/mL. The ethanol extract, ethyl acetate extract have free radical reduction activity, which EC₅₀ values ​​reached 28.9 and 32.0 µg/mL, respectively. The ethanol extract from A. megaphylla Hu exhibited inhibitory activities on gastric, lung and breast cancer cell lines with IC₅₀ values ​​of 56.54, 43.52 and 58.24 µg/mL, respectively. The results show that A. megaphylla Hu is a potential plant that contains many compounds that have antibacterial, antioxidant and anticancer activities.