ETHANOL EXTRACT FROM SAUROPUS ROSTRATUS LEAVES ARREST CELL CYCLE AND INDUCES APOPTOSIS IN HEPG2 LIVE CANCER CELLS

Abstract

Liver cancer is the second most lethal cancer and hepatocellular carcinoma is the most common type of primary liver cancer. Although there have been advances in cancer treatment, however, current anti-cancer chemotherapies still have many limitations, especially post-treatment side effects. This study is aimed to evaluate the cancer cell inhibitory role of ethanol extract from Sauropus rostratus on HepG2 live cancer cells. By cell viability assay (MTT), we showed that the ethanol extract from Sauropus rostratus leaves inhibited the cell proliferation of HepG2 cells in a dose-dependent manner. Flow cytometry analysis revealed that Sauropus rostratus ethanol extract arrested cell cycle at M/G2 phase caused apoptosis with percentage from 15.5 - 32.3% in a dose-dependent menner. The results of this study showed that ethanol extract from Sauropus rostratus has potential against liver cancer cells.