CONCENTRATINON OF ANTI – ANGIOGENIC FACTOR INPREGNANT WOMEN IN THE FIRST TRIMESTER OF PREGNANCY MANAGEMENT OF TEMPLE AT THAI NGUYEN NATIONAL HOSPITAL

Abstract

To determine the concentration of PLGF and SFlt-1 in pregnant women in the first trimester of pregnancy in Thai Nguyen, the study was carried out on 201 pregnant women at high risk of preeclampsia, and 200 normal pregnant women with gestational age from 11 weeksup to 13 weeks and 6 days, using cross-sectional descriptive research method. PLGF and SFlt-1 concentrations were measured by chemiluminescence electrochemical method using Roche dianostig reagent. The result showed that: the concentration of PlGF, sFlt-1, the ratio sFlt-1/PlGF in normal pregnant women with gestational age from 11-13 weeks and 6 days are: 70.3 pg/dl; 1371.5 pg/dl and 18.4. The concentration of PlGF, sFlt-1, the ratio sFlt-1/PlGF in normal pregnant women in our study are different from the reference values ​​recommended by Roche for normal pregnant women at 10-14 weeks gestation. In which, the concentration of PlGF, sFlt-1 was higher, whereas the ratio sFlt-1/PlGF was lower than the reference value of Roche (p<0.05). Pregnant women at risk of pre-eclampsia at the same gestational age: the PLGF level was 52.5 pg/dl; Sflt1: 1678, 9 pg/dl; the sFlt-1/PlGF ratio is 28.9. The concentration of PlGF decreased, the concentration of sFlt-1 and especially the ratio sFlt-1/PlGF increased compared to the concentration and ratio of these factors in normal pregnant women with corresponding gestational age (p<0.001).