STUDY ON MORPHOLOGICAL, PHYTOCHEMICAL PROPERTIES AND ANTI - MICROBIAL ACTIVITY OF AGERATUM CONYZOIDES (LINN.) ASTERACEAE

Abstract

This study aimed to evaluate morphological, phytochemical properties and anti-microbial activites of fractions of Ageratum conyzoides (AC). The sample was collected in Binh Duong province in June 2018 for analyzing its morphology, anatomical characteristics. Preliminary phytochemical screening of the leaves ethanol extract based on the Ciuley’s procedure. Fraction extracts were prepared by partitioning method with solvents n-hexane, chloroform, ethyl acetate, and methanol. Their antimicrobial activities were determined by agar disc diffusion and agar dilution method. Morphological and anatomical characteristics of the parts of the collected plant showed many features of A. conyzoides. Its leaves contained flavonoid, alkaloid, polyphenol, tanin, saponin, reductant and essential oil. The ethylacetate extract exhibited the growth strongest of S. aureus, MRSA, E. coli, P. aeruginosa with MIC value corresponding 125, 125, 500, 500 µg/mL. The choloroform fraction had the strongest antifungal activity, resisted T. rubrum, M. gypseum, T. mentagrophytes with MIC value corresponding 250, 250, 500 µg/mL. The results could provide basic information to isolate and determine the structure of substances with antibacterial and antifungal activities from the potential fractions.